progesteronerx.com

Fertility patients often start progesterone support and want clear routines. A focused page can explain timing and what to expect.

Generic and neutral.

What it is. Progesterone is a natural progestational hormone (micronized for oral use), distinct from synthetic progestins.^[C1][C3]

FDA-approved uses. Oral capsules: preventing endometrial hyperplasia in postmenopausal women with a uterus who take estrogen, and secondary amenorrhea. Vaginal gel and inserts: supporting embryo implantation and early pregnancy in assisted reproduction. Injection in oil: amenorrhea and abnormal uterine bleeding.^[C1][C2][C3]

How it works. It acts on progesterone receptors to transform estrogen-primed endometrium into secretory tissue, protecting it from overgrowth.^[C3]

Forms and strengths. Capsules 100 and 200 mg, vaginal gel 8%, vaginal inserts 100 mg, and injection 50 mg/mL in oil.^[C1][C2][C3]

Key warnings and side effects. The oral product carries a boxed warning (with estrogens): increased risks of cardiovascular disorders, invasive breast cancer and probable dementia in women 65 and older; it should not be used to prevent heart disease or dementia. Contraindicated with undiagnosed vaginal bleeding, breast cancer, active or past blood clots, liver disease, and peanut allergy for capsules containing peanut oil. Drowsiness and dizziness are common.^[C1][C3]