estradiolrx.com

Menopause care has moved into the open, and people want clear, balanced information on hormone therapy. A focused domain can deliver it with clinician oversight.

The name is generic and neutral.

What it is. Estradiol is the main human estrogen, given as a prescription hormone in many forms.^[C1][C3]

FDA-approved uses. Moderate to severe hot flashes and vaginal symptoms of menopause, hypoestrogenism from hypogonadism, castration or primary ovarian failure, prevention of postmenopausal osteoporosis, and palliation of certain breast and prostate cancers.^[C1][C3]

How it works. It binds estrogen receptors in target tissues, replacing the hormone the ovaries no longer make and regulating gene transcription.^[C3]

Forms and strengths. Tablets 0.5, 1 and 2 mg, transdermal patches, gels and sprays, vaginal creams, tablets and rings, and injectable esters.^[C1][C2][C3]

Key warnings and side effects. Boxed warning: estrogen alone increases the risk of endometrial cancer in a woman with a uterus (adding a progestin lowers it), and estrogen therapy carries risks of stroke, blood clots, dementia in women 65 and older, and, with progestins, heart attack and invasive breast cancer. Labeling advises use at the lowest effective dose for the shortest duration consistent with treatment goals. Contraindicated with undiagnosed vaginal bleeding, known or suspected breast or estrogen-dependent cancer, active or past clots, liver disease and pregnancy.^[C1][C3]